March Madness bet strategy must involve careful handicapping that looks at each aspect of each team in any given March Madness betting match up. When you place a March Madness bet, you must always be sure to compare the two teams completely, rather than simply determining that one team is generally better than the other and is therefore a more favorable March Madness bet. Also, you should always take the time to research a lesser known team that you are placing a March Madness bet on in the early rounds of the March Madness betting tournament.