March Madness betting line myths are often hard to put to rest. Let’s see which ones are true and which ones are not as we look at March Madness odds. March Madness wagering lines start in the first round so let’s begin there. A true statement about the first round is that the #1 seed is a pretty good bet. #1 seeds have never lost in the first round and have held their own against the March Madness odds. A myth in regards to March Madness wagering lines is that the favorites always cover in the Final Four. They are actually about .500 over the past few years in March Madness gaming line. Remember that as the tournament progresses the March Madness odds makers do a better job so the lines on the Final Four are usually pretty solid.