March Madness betting lines seeds will show seeds from 1 to 16 in the NCAA Tournament. Which seeds are the best one in terms of March Madness odds? Let’s take a look at the various seedings and how they have done in the tournament. March Madness betting lines seeds in the NCAA Tourney are listed in #1 to #16. The two best seeds in terms of March Madness betting lines are the #10 and the #12. The public and the media have stated the #12 vs. the #5 but very few people have mentioned the #10 vs. the #7 in March Madness odds. That matchup has actually been as good or better in March Madness odds.