March Madness betting lines show definite trends throughout the NCAA Tournament. During the past few years the best performing seed against the March Madness odds lines has been the #10 seed. They are hitting at about 70% against the March Madness odds. March Madness wagering lines show that the #8 seeds have done pretty well hitting almost 70% against the spread the past few years. The worst seeds in March Madness betting lines are usually the #4 seeds in the early rounds. They have hit below 50% against the March Madness wagering lines. Overall the seed that really struggles is the #7 seed. That makes sense since the #10 seed does the best in March Madness odds and the 10 versus 7 matchup occurs four times every year in the first round.