March Madness betting is something that many gamblers around the world look forward to with great excitement. March Madness betting is something special, and it is also something that we can make money at if we do our homework. March Madness wagering has some systems and trends that have done fairly well over the years. In the first round taking the underdog is always worth a long look and certain matchups have done well. The five-twelve, four-thirteen, and three-fourteen matchups have had definite trends. Usually taking the dog in the 5-12 and 4-12 matchups will make you money in March Madness betting. Surprisingly taking the favorite in the 3-14 game will show a profit in March Madness wagering.