Sweet sixteen betting on Thursday in the West Region has the #1 seed Connecticut facing the #5 seed Purdue. The Huskies are 6.5 point favorites in March Madness odds in this matchup. Sweet sixteen betting numbers tell us that Purdue is 27-9 straight up and 15-17 against the spread. Connecticut is 29-4 straight up and 13-14 against the pointspread. The Huskies have been the most impressive team so far in Sweet sixteen betting as they routed Chattanooga in the first round and Texas A&M in the second round. Guard A.J. Price is red-hot, scoring 20 points in the first round and 27 in the second round. Hasheem Thabeet hasn’t really been needed but that will change in this game against Purdue. Jeff Adrien has also been a big force for the Huskies and he can impact Sweet sixteen betting odds.