Football betting on the Arizona Cardinals vs. San Francisco 49ers game will focus on the starting quarterbacks as Kurt Warner won the job for Arizona while J.T. O’Sullivan leads the 49ers. Football betting stats show that the Cardinals went 8-8 straight up last season and 9-7 against the spread while San Francisco went 5-11 both straight up and against the NFL betting pointspread. Arizona is a three point favorite in NFL Odds Week 1 action with a total of 41.5. Football betting could favor the Cardinals in this matchup, especially with Warner at the helm. Arizona is expected to contend for the playoffs this season under head coach Ken Whisenhunt while San Francisco would be happy to just get near .500 under head coach Mike Nolan. Football betting stats show that the Cardinals were 12th overall in offense last season and seventh in points per game. The Cardinals were about average on defense, ranking 17th in the league according to football betting numbers.