Football betting on Saturday includes a matchup between the Indianapolis Colts and Carolina Panthers The two teams are meeting for the first time ever in NFL betting preseason action. NFL week 1 odds have the Panthers as a 3.5 point football betting favorite with a total of 35.5. Football betting stats show that the teams have met four times in regular season action with the Panthers holding a 3-1 series edge. The Colts opened football betting preseason action last week in the Hall of Fame game and they lost to Washington 30-16. Many starters for the Colts did not play including quarterback Peyton Manning and that impacted the football betting outcome in the game against Washington. The Indianapolis Colts will be without a number of starters again this week including Manning, Dwight Freeney and Bob Sanders according to football betting injury information. Backup quarterback Jim Sorgi should play more than just the one series he played last week according to NFL betting experts. The Colts are 2-11 straight up and 3-10 versus the football betting number the past three preseasons.