Jimmy Garoppolo is again hurting for the 49ers. The cause of Jimmy G’s frequent injuries was Trey Lance, drafted last April. Garoppolo is one of the NFL’s best game managers. But his inability to stay in the lineup has frustrated head coach Kyle Shanahan. Further, it has put great betting on NFL stress on the rest of the team. San Francisco is fighting to stay in the NFC playoff race. Following three losses in five games, the pressure is on full blast. Defensively the strain of covering for an inconsistent offense is reaching the breaking point.
Indianapolis Colts vs. San Francisco 49ers NFL Betting Information
| Date and Time: | Sunday, October 24, 2021, 8:20 p.m. ET |
|---|---|
| Location: | Levi’s Stadium, Santa Clara, California |
| Colts at 49ers TV Coverage: | NBC |
| Team | Spread | Total | ML | |
|---|---|---|---|---|
| Colts | +4 (-105) | 44 (-110) | +170 |  |
| 49ers | -4 (-115) | 44 (-110) | -200 | |
| ||||
Indianapolis Colts at San Francisco 49ers SBG Odds Overview
In this situation, the 49ers will draw Wise Guys based on their online wagering Price break. Cause by San Francisco’s slow start, oddsmakers have lowered the price to entice a skeptical public.
Indianapolis Colts Team Overview
Last week Indianapolis beat Houston 31-3 as 11.5-point home favorites. The game went under the total of 45.5. As a result, the Colts are 2-4 straight up, 4-2 against the spread, and 3-3 over/under. Indianapolis ranks 15th for total offense and 19th for scoring offense. Defensively, the Colts rank 20th overall and 11th for points allowed.
Carson Wentz threw two long TD passes. At the same time, Jonathan Taylor had 14 carries for 145 yards.
San Francisco 49ers Team Overview
Last week the 49ers were on a bye week. Following a 17-10 loss at Arizona as 6-point dogs. The game went under the total of 48.5. As a result, San Francisco is 2-3 straight up, 1-4 against the spread, and 2-3 over/under. The 49ers rank 14th for total offense and 17th for scoring offense. Defensively, San Francisco ranks 6th overall and 15th for points allowed. As a result of the loss, the Niners have dropped three in a row.
Indianapolis Colts at San Francisco 49ers Against the spread
- On the road, Indianapolis is 61% against the spread
- As an underdog, the Colts are 54% vs. the odds
- In non-conference action, Indianapolis is 77% against the spread
- As an away team, the Colts are 65% over the total
- As an underdog, Indianapolis is 60% over the total
- In inter-conference games, the Colts are 50% over/under the total
- At home, San Francisco is 41% against the spread
- As a favorite, the 49ers are 37% vs. the odds
- In non-conference action, the 49ers are 55% against the spread
- As a home team, San Francisco is 55% over the total
- As a favorite, the 49ers are 58% over/under the total
- In non-conference games, San Francisco is 44% over/under the total
- Indianapolis is 5-2 against the spread vs. San Francisco
- The Colts and 49ers are 1-3 over/under the total
- At San Francisco, the Colts are 3-0 vs. the odds against the 49ers
- These two teams are 0-2 over/under the total at San Francisco.
Indianapolis Colts at San Francisco 49ers SBG Free Picks
In this situation, the 49ers will be fresh after their Betting on NFL bye week. Two weeks to prepare and heal should be the difference.
Colts at 49ers SBG Best Bet: San Francisco 49ers.