NFL Preseason: 49ers vs. Chargers Betting Preview, Odds and Picks (August 22, 2021)

Last week the Chargers won “on the road” in the stadium that they call home. To illuminate, the Rams and Chargers share SoFi Stadium, and the Rams were designated as the home team. It was a successful debut for Chargers coach Brandon Staley. Accordingly, the Chargers are seen as one of the top surprise candidates with the NFL betting odds. Meanwhile, the 49ers continue to sort through their quarterback controversy. Trey Lance is challenging Jimmy Garoppolo for the number one job. Hence, Lance had an erratic debut in his first game as a pro last week.

San Francisco 49ers vs. Los Angeles Chargers NFL Betting Information

Date and Time:Sunday, August 22, 2021, 7:30 p.m. ET
Location:SoFi Stadium, Inglewood, California
49ers at Chargers TV Coverage:NFL Network
49ers vs. Chargers Odds at SBG Sportsbook
TeamSpreadTotalML
49ers-4½ (-110)34 (-110)-245
Chargers+4½ (-110)34 (-110)+195
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San Francisco 49ers at Los Angeles Chargers SBG Odds Overview

In this situation, the Chargers are looking at depth players. Los Angeles is trying to solidify its lineup around quarterback Justin Herbert. San Francisco will continue to give Trey Lance every opportunity to win the starting job from Garoppolo. Thus, live betting will get plenty of online betting activity. And the Chargers are a potentially attractive home dog to some. But San Francisco has appeal in its own right as a team prepping for a playoff charge.

San Francisco 49ers Team Overview

Last week the 49ers lost to the Chiefs 19-16 as 2.5-point home favorites. The game stayed under the total of 37. Kansas City won the game on a touchdown with 1:14 to play. San Francisco outgained the Chiefs 383-258 but suffered two turnovers. Additionally, the 49ers committed seven penalties. First-round draft pick Trey Lance was 5-14 for 128 yards and one touchdown passing. It was his pro debut. Lance hit Trent Sherfield for an 80-yard touchdown pass in the first quarter. Jamycal Hasty ran for 63 yards on ten attempts with one touchdown.

Los Angeles Chargers Team Overview

Last week the Chargers beat the Rams 13-6 as 3.5-point away chalks. Under the total of 32.5 was a winning ticket as well. The Chargers outgained the Rams 259-197. Chase Daniel led the Chargers with 15-24 for 104 yards passing. At the same time, Larry Rountree ran for 63 yards on eight attempts.

San Francisco 49ers at Los Angeles Chargers Against the Spread

  • San Francisco is 6-1-1 against the spread in preseason road games
  • The 49ers are 3-6 under the total in exhibition away matchups
  • San Francisco is 3-8 vs. the odds as preseason chalk
  • The 49ers are 4-10 under the total as exhibition favorites
  • The Chargers are 4-8 against the spread as preseason dogs
  • LA is 4-3 over the total getting points in exhibition games
  • At home in the preseason, the Chargers are 2-5 against the spread
  • LA is 1-4 under the total at home in exhibition games
  • The Chargers are 3-2 against the spread in the preseason vs. the 49ers
  • The 49ers and Chargers are 3-1 over the total in their preseason meetings
  • The Chargers and 49ers are 2-0 to the over when the 49ers are the away team
  • The 49ers are 4-1-1 vs. the odds in the preseason at the Chargers

San Francisco 49ers at Los Angeles Chargers SBG Free Picks

Of great concern is the Chargers’ poor value for Pro football Bets as preseason dogs. Additionally, the Chargers are deeply in the red as a preseason home team.

49ers at Chargers SBG Best Bet: San Francisco 49ers.